ABSTRACT
Five patients with HIV associated cutaneous cryptococcal infection are reported.
ABSTRACT
Cryptococcal meningitis is an emerging opportunistic infection among HIV infected patients and an important cause of mortality among these patients. The incidence of cryptococcal meningitis varies from place to place. A total of 31 specimens of CSF out of 89 samples processed from known HIV positive cases yielded Cryptococcus neoformans during the period of 3 years. C.neoformans was the most common opportunistic pathogen isolated from CSF samples of these patients with an incidence of 34.8%
ABSTRACT
Administration of amiodarone (AD) to rats leads to marked damage to liver, as evidenced by pathological changes and significant increases in activities of serum marker enzymes and levels of lipids like cholesterol and phospholipids with no alteration in the triglyceride levels. The risk factor, that is the total cholesterol/HDL cholesterol ratio, exhibited increase in the experimental animals, indicating that amiodarone treatment may lead to the development of coronary heart disease.
Subject(s)
Alanine Transaminase/metabolism , Alkaline Phosphatase/metabolism , Amiodarone/pharmacology , Animals , Aspartate Aminotransferases/metabolism , Cholesterol/blood , Isoenzymes/metabolism , L-Lactate Dehydrogenase/metabolism , Lipid Metabolism , Lipids/blood , Liver/drug effects , Male , Phospholipids/metabolism , Rats , Rats, Wistar , Triglycerides/metabolismABSTRACT
The effect of Amiodarone (AD), a cationic amphiphilic drug, on erythrocytes and leucocytes was studied. Treatment of rats with AD showed a significant decrease in the red cell count and the level of Hemoglobin. Amiodarone altered the fluidity of the erythrocyte membrane followed by a decrease in the activities of membrane bound enzymes like (Na+, K+)-ATPase, Acetylcholine esterase and NADH dehydrogenase. A slight increase in the leucocyte count was also observed in the treated animals.
Subject(s)
Amiodarone/pharmacology , Animals , Cholesterol/metabolism , Erythrocyte Count/drug effects , Erythrocyte Membrane/drug effects , Hemoglobins/metabolism , Leukocyte Count/drug effects , Male , Membrane Fluidity/drug effects , Phospholipids/metabolism , Rats , Rats, Wistar , Sodium-Potassium-Exchanging ATPase/bloodABSTRACT
Administration of single dose (175 mg/kg body wt) of amiodarone dissolved in water through gavage for 3 weeks damaged the lung and changed the content of lung lavage. Activities of bronchoalveolar lavage (BAL) angiotensin converting enzyme (ACE) and lactate dehydrogenase (LDH) increased significantly. Also, the protein and lactate content of the lavage fluid increased significantly over the control. The drug also produced marked changes in morphology of the lung of experimental animals.